|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the fact that the expression of ADS31/YPT1 transcript becomes dominant in the advanced stages of androgen-independent growth, suggests that the mechanism of progression is subserved by duplication and possibly redundancy of alternative (signal transduction) pathways mediating tumour cell survival and growth.
|
8049130 |
1994 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tumor‑node‑metastasis (TNM) stage.
|
30896866 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that Rab1A was significantly overexpressed in the different histological types of lung cancer as compared to non-cancerous tissues, and Rab1A expression was correlated with tumor volume and stage.
|
27902464 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High expression of Rab1A was closely related to the tumor size and the depth of tumor invasion.
|
31038077 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The level of p‑S6K1 was markedly high in CRC tissues and Rab1A expression level had a positive association with p‑S6K1 level.
|
30896866 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and western blot were conducted to determine the RAB1A expression in CRC tissues and cells, respectively.
|
31598673 |
2020 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Kaplan-Meier survival analysis showed that patients with high Rab1A expression had a significantly worse survival time than those with low Rab1A expression, which especially affected the survival in CRC patients with advanced stage.
|
30058685 |
2018 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson's disease.
|
27041585 |
2016 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We detected significantly higher expression of Rab1A in the gastrointestinal tumor tissues compared to that in other cancer types following an in silico analysis of TGCA and GTEX databases.
|
31527621 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Meanwhile, high Rab1A expression was significantly associated with the TNM stage, lymph node metastasis, and peritoneal metastasis.
|
30058685 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Collectively, this study suggested that circ_0000218 up-regulated RAB1A and promoted CRC proliferation and metastasis via sponging miR-139-3p.
|
31598673 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
|
30058685 |
2018 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry (IHC) was performed to explore the association of Rab1A/p-S6K/Gli1 expression and prognosis in 117 GC tissue samples and adjacent normal tissues.
|
31038077 |
2019 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In recent years, the aberrant expression of RAB1A has been reported in a number of tumours, but its regulation in GC has not been extensively examined.
|
29552156 |
2018 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson's disease.
|
27041585 |
2016 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of Rab1, the mammalian YPT1 homolog, protected against alphaSyn-induced dopaminergic neuron loss in animal models of PD.
|
16794039 |
2006 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.
|
23939344 |
2011 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In recent years, the aberrant expression of RAB1A has been reported in a number of tumours, but its regulation in GC has not been extensively examined.
|
29552156 |
2018 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry (IHC) was performed to explore the association of Rab1A/p-S6K/Gli1 expression and prognosis in 117 GC tissue samples and adjacent normal tissues.
|
31038077 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tumor‑node‑metastasis (TNM) stage.
|
30896866 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of Rab1A was closely related to the tumor size and the depth of tumor invasion.
|
31038077 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson's disease.
|
27041585 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We detected significantly higher expression of Rab1A in the gastrointestinal tumor tissues compared to that in other cancer types following an in silico analysis of TGCA and GTEX databases.
|
31527621 |
2019 |
|
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In multiple independent mouse lines, Rab1a overexpression caused cardiac hypertrophy that progressed in a time- and transgene dose-dependent manner to heart failure.
|
11739277 |
2001 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In multiple independent mouse lines, Rab1a overexpression caused cardiac hypertrophy that progressed in a time- and transgene dose-dependent manner to heart failure.
|
11739277 |
2001 |